Beauty comes from within. Stability too.

Clinical routine shows that stability plays an important role during the early stages of implantology treatment. The quicker and more intensive the osseointegration process, the higher the implant stability. Dexabone is an incomparably stable, highly purified, and well established spongiosa bone graft material of bovine origin. It goes further towards satisfying the requirements for increased safety and better predictability. The material is used for oral guided bone regeneration (GBR) in the management of simple and complicated defects to build up the bone bed. The mineral composition, the crystalline structure, and the spongiosa structure of Dexabone are very similar to those in the human body. Therefore, Dexabone achieves the same elasticity, strength and stability in the patient’s jaw after integration as the body’s own jaw bone.

Dexabone is eminently suitable for all augmentation techniques for building up a strong implant bed and treating periodontal defects. Dexabone is the material of choice for functional and aesthetic reconstructions for natural, reliable, simple and economic bone regeneration. In combination with autologous bone and other bone graft materials as well. Thanks to the particularly high degree of purity of the hydroxyapatite of bovine origin and the physiological pH of 8.2, the outstanding homogeneity of the hydroxyapatite structure and the interconnecting macropores of the natural bone, Dexabone is superior to other hydroxyapatite ceramics.

Table: Mechanical properties of Dexabone

Perfection is rare. Purity too.

The development of a single-phase hydroxyapatite such as Dexabone was prompted by the trend towards increased safety and better predictability. The focus on the body’s biological healing processes demanded a material that does not contaminate the healing process in the body with phase impurities. The phase content of Dexabone as measured by X-ray diffractograms shows phase pure hydroxyapatite. Dexabone is pure and 100% safe (BSE) and 100% protein-free. Thus Dexabone does not contain any phase constituents that impair the healing process. This means better clinical safety for therapist and patient alike. In this way, Dexabone exploits the natural and perfect healing potential of the humanbody right from the start.

Diffraction pattern of natural bone;
Dexabone; HA of algae and Tricalcium phosphate

Therapies need acceptance. Performance too.  

Dexabone – Biofunctionality  
The excellent acceptance and biocompatibility of hydroxyapatite and Dexabone spring from its material properties. The other properties of Dexabone are based on the open interconnecting pore structure. This is identical to the biological characteristics of the bovine starting material and arises from the physiological structure of the human body. Dexabone’s macroporous structure is ideal in its osteoconductive function and promotes the ingrowth of blood vessels and nerves. The adhesion and spread of osteoblasts over the Dexabone surface creates an open, interconnecting pore structure, which prompts a bioactive reaction with bone tissue formation, bone tissue strengthening and bone tissue interlinking leading to the restoration of the bone and its function. The osteoconductive properties of hydroxyapatite ceramic have been demonstrated without doubt by biopsies.

Dexabone – Long-term success  
The very good acceptance of Dexabone is seen in its efficacy. Hydroxyapatite of bovine origin has been successfully used in clinical medicine since 1989. Radiological follow- ups after 3 and 6 months showed consolidation of the defects that was consistent with the healing phase. Biopsies retrieved from clinical grafts showed that the ceramic had almost completely been surrounded by bone and that newly formed bone had also been deposited inside the ceramic pores. The long-term results were also confirmed by a large number of studies and clinical applications.  

Dexabone – Tolerability  
The bone graft material Dexabone is extremely well tolerated. Its pH of 8.2 matches the physiological levels, which is particularly important during the early stages of implantation. Dexabone does not contain any pharmacologically active constituents. Large patient populations have confirmed the good biocompatibility of hydroxyapatite ceramic. Not one single rejection reaction has been reported to date.  

Dexabone – Administration
The Dexabone material is very hydrophilic and can easily be mixed with saline or the patient’s blood before insertion. The Dexabone/blood mixture demonstrates excellent coagulation properties and can be taken off the spatula confidently and applied with pinpoint accuracy. Bone regeneration can be promoted in combination with autologous blood and bone.  

Dexabone is supplied in double sterile bottles ready for use

The good integrated HA-ceramic fragments are visible macroscopically.	Staining with toluidin blue. Well structured trabecular bone with numerous osteoblasts on the trabecular and ceramic surface

Literature

Long-term outcomes after using porous hydroxyapatite ceramics (Endobon) for surgical management of fractures of the head of the tibia Briem D, Linhart W, Lehmann W, Meenen NM, Rueger JM. Unfallchirurg. 2002 Feb;105(2):128-33. German.  

Evaluation of hydroxyapatite implants in vertebral bodies and extremities by contrast-enhanced magnetic resonance imaging Grimm J, Mueller-Huelsbeck S, Mueller M, Egbers HJ, Brinkmann G, Heller M. Arch Orthop Trauma Surg. 2001;121(3):158-61.  

Osseous integration of bovine hydroxyapatite ceramic in metaphyseal bone defects of the distal radius Werber KD, Brauer RB, Weiss W, Becker K. J Hand Surg [Am]. 2000 Sep;25(5):833-41.  

Hydroxyapatite ceramics in clinical application. Histological findings in 23 patients Liebendörfer A, Tröster S. Unfallchirurgie. 1997 Apr;23(2):60-8. German.

Clinical Cases

X-ray of dental cyst, maxilla lt.	situation before Cystectomy	situation after Cystectomy
defect augmentation utilizing Dexabone	defect  augmentation utilizing Dexabone & Hyprosorb membrane	defect  augmentation utilizing Dexabone & Hyprosorb membrane
Courtesy of prof.Dr.med.dent.N.Watted, Center for Dentistry & Esthetics
Lateral sinus window	Situation of perforated sinus membrane	Application of Hyprosorb Membrane by perforated sinus membrane
Dexabone filling of the sinus	Hyprosorb membrane before sinus window closing	Situation after bilateral flap closure
Courtesy of Dr.med.dent.Ph.D. Fahim Atamni
Hyprosorb membrane &Dexabone	x-ray dental cyst, maxilla lt.	situation before Cystectomy
situation after Cystectomy	defect augmentation utilizing Dexabone & Hyprosorb membrane	x-ray after bone augmentation utilizing Dexabone.
Courtesy of prof.Dr.med.dent.N.Watted, Center for Dentistry & Esthetics